Separation of Pharmaceutical Enantiomers using Supercritical Fluid Technology
نویسنده
چکیده
The use of supercritical fluids as chromatographic mobile phases provides rapid separations with high efficiency, favoring their use in enantioselective separations. Supercritical fluid technology (SFC) is a versatile tool in the purification, enantioseparation and large-scale production of enantiomers of pharmaceuticals over comparable liquid chromatographic methods and is gaining popularity in pharmaceutical industry. The addition of organic modifiers and additives to the supercritical carbon dioxide mobile phase extends the utility of packed column SFC to polar and even ionic compounds. SFC/MS is employed for detection of impurity and confirmation / identification of enantiomers.
منابع مشابه
Simulation of Separation of a Racemic Mixture of Ibuprofen by Supercritical Fluid Chromatography in Simulated Moving Bed
Separation of a racemic mixture of ibuprofen at a low concentration level by supercritical fluid chromatography in a simulated moving bed (SFC-SMB) is investigated by simulation. The feasibility of ibuprofen enantiomers separation has been experimentally examined in the literature. Our simulation results show that separation of ibuprofen enantiomers is feasible by this method, and R-ibuprofen a...
متن کاملEnantioselective Analytical- and Preparative-Scale Separation of Hexabromocyclododecane Stereoisomers Using Packed Column Supercritical Fluid Chromatography.
Hexabromocyclododecane (HBCDD) is an additive brominated flame retardant which has been listed in Annex A of the Stockholm Convention for elimination of production and use. It has been reported to persist in the environment and has the potential for enantiomer-specific degradation, accumulation, or both, making enantioselective analyses increasingly important. The six main stereoisomers of tech...
متن کاملSupercritical Fluid Technology: An Overview of Pharmaceutical Applications
Supercritical fluid technologies (SCFT) represent a recent approach for obtaining pharmaceutical materials in pure physical form and the application of supercritical fluids is a superior alternative to conventional precipitation and extraction processes. Supercritical fluid technology (SCFT) offers exciting opportunities to produce and modify pharmaceutical substances and has the potential to r...
متن کاملEnantioseparation in CE using macrocyclic antibiotics as chiral selectors
Enantiomer separation represents an important topic especially in pharmaceutical and environmental fields where many drugs and pesticides are racemic compounds. In some cases, only one of the enantiomers has pharmacological or pesticidal activity while the other may exhibit antagonistic activities, unwanted side effects or even toxic effects. Therefore, the development of new enantioseparation ...
متن کاملProfiling the Isomerization of Biologically Relevant (E)-(Z) Isomers by Supercritical Fluid Chromatography (SFC)
In the past few decades, single enantiomers and stereoisomers have overtaken achiral molecules in the percentage of approved drugs in the market. Because isomers can have different biological/pharmacological/toxicological properties, authorities such as the European Pharmacopoeia and the FDA have asserted escalated emphasis on controlling isomer content in drug compounds and require that stereo...
متن کامل